|
|
|
| e-Pub |
Previous | 
Home
Section: New Results
Biological Image Analysis
Pre-clinical molecular imaging: motionless 3D image reconstruction in micro-SPECT
Participants : Marine Breuilly [Correspondant, Inria] , Grégoire Malandain [Inria] , Nicholas Ayache [Inria] , Jacques Darcourt [UNS-CAL] , Philippe Franken [UNS-CAL] , Thierry Pourcher [CEA] .
This work is jointly conducted with the Transporter in Imagery and Oncologic Radiotherapy team (TIRO, CEA-CAL-UNSA) located in Nice.
SPECT/CT, small animal, respiratory motion, respiratory gating, 4D images, stomach, 99mTc-pertechnetate biodistribution, compartmental analysis
This work has been conducted on SPECT images acquired with a small animal device. Dynamic SPECT images provide functional information targeted by a specific radiotracer (99mTc-pertechnetate) that permit the tracking and quantifying of evolving phenomena.
-
Respiratory motion induces an artificial enlargement of the moving structures (tumours, organs) in SPECT images, and biases the quantification.
-
A full ad-hoc method was presented that allows the reconstruction of a single 3D SPECT image without motion artefacts [37] , [6] , [1] .
Pre-clinical molecular dynamic imaging: Tc-pertechnetate biodistribution model of murine stomach with micro-SPECT
Participants : Marine Breuilly [Correspondant, Inria] , Grégoire Malandain [Inria] , Nicholas Ayache [Inria] , Jacques Darcourt [UNS-CAL] , Philippe Franken [UNS-CAL] , Thierry Pourcher [CEA] .
This work is jointly conducted with the Transporter in Imagery and Oncologic Radiotherapy team (TIRO, CEA-CAL-UNSA) located in Nice.
SPECT/CT, small animal, 4D images, stomach, Tc-pertechnetate biodistribution, compartmental analysis
Using the coupled SPECT and CT device dedicated to small animals, functional information targeted by a specific radiotracer (Tc-pertechnetate) can be imaged dynamically.
-
Tc-pertechnetate is an iodide analog related to the NIS gene. Thus iodide uptake kinetics can be studied through the study of Tc- pertechnetate biodistribution.
-
Dynamic SPECT images exhibit a progressive accumulation of
Tc-pertechnetate in the stomach wall and diffusion in the stomach cavity.
-
A first simplified model for stomach Tc-pertechnetate biodistribution was proposed and studied with a compartmental analysis approach using a simplified two-compartment (stomach wall and cavity) model with one input (blood) (see Figure 4 ) [1] .
-
Time activity curves of each compartment were obtained from dynamic images thanks to an original layer-based decomposition of the stomach [1] .
-
The first estimation of the model transfer parameters was performed by numerically solving the inverse problem [1] .
